Abstract Session: Non-prostate Genitourinary Cancers

Prostate / Genitourinary Cancers

Young Investigator Abstract Session - Vascular

Background: Endothelial cell (EC) maladaptation to disturbed blood flow at predilection sites of atherosclerosis is characterized by inflammation and defective regeneration. The RNase Dicer is essential for the production of microRNAs, which play a crucial role in EC maladaptation. EC-derived Dicer promotes atherosclerosis and suppresses KLF4, Notch1, and Wnt signaling. While Dicer increases EC...

Session IV: Prostate Prostate cancer and imaging

Prostate cancer’s incidence, prevalence, etiology, and risk factors, and the influence of clinical trials on imaging technology development are discussed. One in seven Western men older than 70 will develop prostate cancer. The advent of prostate-specific antigen (PSA) screening means most men will now be diagnosed with early disease (85% not palpable on digital rectal exam (DRE), fewer grade 8...

Mechanisms of Progranulin Action and Regulation in Genitourinary Cancers

The growth factor progranulin has emerged in recent years as a critical regulator of transformation in several cancer models, including breast cancer, glioblastomas, leukemias, and hepatocellular carcinomas. Several laboratories, including ours, have also demonstrated an important role of progranulin in several genitourinary cancers, including ovarian, endometrial, cervical, prostate, and bladd...

AB011. Systematic analysis of the genomic landscapes of genitourinary cancers

60 vs. 61 to 90 degrees) and randomized to CCh or placebo 2:1 in favour of the former. Post hoc meta-analysis of IMPRESS I and II data revealed that men treated with CCh showed a mean 34% improvement in penile curvature, representing a mean ±SD −17.0±14.8 degree change per subject, compared with a mean 18.2% improvement in placebo treated men, representing a mean −9.3±13.6 degree change per sub...